That which we once thought nothing of and discarded in anatomy class as trash, provides a treasure of information that can teach us better ways to understand and treat pain. Fascia is the most important generator of pain and proprioception in the body. Muscle, fascia, radiating myofascial pain, prolotherapy, trigger point injections, ozonotherapy, PRP injections, acupuncture, and the use of compounding pharmacy take on new meaning with a more up-to-date understanding of anatomy that is based on new techniques of fascia sparing dissection. Contrary to the way pain practitioners have been taught, there is now a need to deemphasize medication and promote non-pharmaceutical treatment options for patients. Specific qualities and symptoms of pain blur as we reconsider our understanding of neuropathic and sympathetically mediated pain. Changing this perspective will allow you to rethink the circle of injury, pain, and healing in a way that could revolutionize your practice and better the lives of your patients.